ea0042p8 | (1) | Androgens2016
Knuuttila Matias
, Mehmood Arfa
, Huhtaniemi Riikka
, Oksala Riikka
, Hakkinen Merja
, Laajala Teemu D
, Aittokallio Tero
, Auriola Seppo
, Ohlsson Claes
, Elo-Uhlgren Laura
, Sipila Petra
, Makela Sari
, Poutanen Matti
The growth of prostate cancer (PCa) can be suppressed by androgen deprivation therapy (ADT). However, in a significant proportion of men receiving ADT PCa progresses to castration-resistant prostate cancer, associated with activation of intratumoral androgen biosynthesis and induced androgen receptor (AR) expression. Accordingly, we have recently shown that the castration-resistant VCaP (CR-VCaP) xenografts express high level of AR and retain detectable intratumoral androgen c...